Mepact can be administered on an inpatient or outpatient basis1

Mepact must be reconstituted using the filter provided and further diluted prior to administration. The reconstituted suspension for infusion is a homogenous, white to off-white, opaque liposomal suspension, free of visible particles and free of foam and lipid lumps. After reconstitution, Mepact is administered by intravenous infusion over a period of one hour. Mepact must not be administered as a bolus injection.2

How frequently should Mepact be administered?

Mepact is given by intravenous infusion over the course of one hour, twice a week for 12 weeks, then once weekly for 24 additional weeks – a total of 36 weeks of therapy, or 48 infusions.2

First 12 weeks

Twice weekly at least 3 days apart. Total: 24 infusions

Next 24 weeks

Twice weekly at least 3 days apart. Total: 24 infusions

The recommended dose for all patients is 2 mg/m2 body surface area.

Mepact therapy:

  • Can be adjusted to fit with the adjuvant combination chemotherapy schedule
  • Need not be interrupted due to delays in the chemotherapy regimen1 
  • Should not be mixed with other drugs2

Separate the administration times of mifamurtide and doxorubicin or other lipophilic medicinal products if used in the same chemotherapy regimen.2

It is recommended that the reconstitution of the liposomal suspension should be performed in a laminar flow cabinet utilising sterile gloves using aseptic technique. The lyophilised powder should be allowed to reach a temperature between approximately 20°C–25°C prior to reconstitution, filtering using the filter provided and dilution. This should take approximately 30 minutes.

Please refer to the Safety and tolerability section for overdose information.

Materials provided in each package:

  • 1 vial of Mepact (mifamurtide)
  • 1 filter for Mepact

Materials required but not provided:

  • Sodium chloride 9 mg/ml (0.9%) solution for injection, 100 ml bag
  • One single use 60 or 100 ml sterile syringe with luer lock
  • Two medium (18) gauge sterile injection needles

Storing Mepact:

Unopened vial

Store in a refrigerator (2°C–8°C). Do not freeze. Keep the vial in outer carton in order to protect from light

Reconstituted suspension

Once reconstituted in sodium chloride 9 mg/ml (0.9%) solution, store at room temperature (approximately 20°C–25°C) and use within 6 hours